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Mucins In Cancer Function Prognosis And Therapy Pdf

mucins in cancer function prognosis and therapy pdf

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This is an open access article distributed under the terms of Creative Commons Attribution License. The mucin family of proteins are high-molecular-weight glycoproteins, which provide protection for the epithelial cell lining that is exposed to the external environment 1.

Overexpression of MUC1 predicts poor prognosis in patients with breast cancer

A dynamic mucosal layer shields the epithelial cells lining the body cavities and is made up of high molecular weight, heavily glycosylated, multidomain proteins called mucins. Mucins, broadly grouped into transmembrane and secreted mucins, are the first responders to any mechanical or chemical insult to the epithelia and help maintain tissue homeostasis. However, their intrinsic properties to protect and repair the epithelia are exploited during oncogenic processes, where mucins are metamorphosed to aid the tumor cells in their malignant journey. Several obstacles have limited the study of mucins, including technical difficulties in working with these huge glycoproteins, the dearth of scientific tools, and lack of animal models; thus, the tissue-dependent and domain-specific roles of mucins during mucosal protection, chronic inflammation, tumorigenesis, and hematological dissemination of malignant cells are still unclear. Future studies should try to integrate information on the rheological, molecular, and biological characteristics of mucins to comprehensively delineate their pathophysiological role and evaluate their suitability as targets in future diagnostic and therapeutic strategies.

Unraveling mucin domains in cancer and metastasis: when protectors become predators

This is an open access article distributed under the terms of Creative Commons Attribution License. Although progress in the early detection, diagnosis and treatment of breast cancer has been achieved in recent decades, the disease remains a significant global health burden 3 , 4. Accurate biomarkers for early diagnosis and more accurate prognosis could improve the efficiency of current treatments for breast cancer and represent molecular markers for targeted therapy 5. Therefore, the identification of specific and sensitive molecular biomarkers involved in breast cancer has a crucial clinical significance. Mucin 1 MUC1 is a transmembrane glycoprotein and is the most thoroughly researched tumor-associated antigen 6 — 8. As a cell membrane glycoprotein, MUC1 is normally expressed at low levels on the apical surfaces of epithelial cells, including in the pancreas, breast, lung and gastrointestinal tract 9. Additionally, MUC1 has become a topic of concern in the treatment of cancer due its upregulation possibly affecting the invasion, proliferation and survival of tumor cells by reducing cell-cell adhesion and cell-extracellular matrix adhesion 10 —

The meta-analysis included 11 studies patients. There were no associations between low MUC2 expression level and gender, histological grade, depth of invasion, and distant metastasis. The low levels of MUC2 in CRC tissues are poor prognostic factor independent of stage or other well-recognized markers of later-stage disease. Colorectal cancer CRC is associated with substantial morbidity and is ranked the third leading cause of cancer-related mortality in the world [ 1 , 2 ]. Recurrence is very common in CRC [ 4 , 5 ], and there is a high risk of subsequent primary cancers in the colon, rectum, and other parts of the digestive system [ 6 ]. CRC incidence and mortality rates are rising rapidly in many low- and middle-income countries.

Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

P Q7Z Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. MUC1 has a core protein mass of kDa which increases to kDa with glycosylation. The protein is anchored to the apical surface of many epithelia by a transmembrane domain.

Metrics details. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival.

Cholangiocarcinoma CCA is rare but often highly fatal tumour arising from the biliary tract epithelium. It encompasses three distinct anatomic categories, namely intrahepatic iCCA , perihilar pCCA and distal dCCA which exhibit different clinical and pathological features. All three types of CCA present diagnostic challenges. In particular, a presumed diagnosis of iCCA can be made on radiological criteria only in the absence of extrahepatic primary solid tumours and liver cirrhosis.

Unraveling mucin domains in cancer and metastasis: when protectors become predators

Differential expression of mucins in Middle Eastern patients with colorectal cancer

Его дыхание стало ровным. - Сьюзан.  - Голос его прозвучал резко, но спокойно.  - Тебе удалось стереть электронную почту Хейла.

Празднично одетые испанцы выходили из дверей и ворот на улицу, оживленно разговаривая и смеясь. Халохот, спустившись вниз по улочке, смачно выругался. Сначала от Беккера его отделяла лишь одна супружеская пара, и он надеялся, что они куда-нибудь свернут. Но колокольный звон растекался по улочке, призывая людей выйти из своих домов. Появилась вторая пара, с детьми, и шумно приветствовала соседей. Они болтали, смеялись и троекратно целовали друг друга в щеки.

Что-нибудь, что можно было бы вычесть одно из другого. - Три минуты! - послышался крик. - А сверхкритическая масса? - предложила Соши.  - Тут сказано, что сверхкритическая масса плутония составляет тридцать пять и две десятых фунта. - Вот именно! - крикнул Джабба.  - Посмотрите уран.

Для расшифровки Беккеру нужно было всего лишь подставить вместо имеющихся букв те, что следовали непосредственно за ними: А превращалось в В, В - в С и так далее. Беккер быстро проделал это со всеми буквами. Он никогда не думал, что четыре слова могут сделать его таким счастливым: IM GLAD WE MET Что означало: Я рада, что мы встретились. Он быстро нацарапал на программке ответ и протянул Сьюзан: LDSNN Сьюзан, прочитав, просияла. ME TOO, что означало: Я .

 - Гамма-лучи против электромагнитной пульсации. Распадающиеся материалы и нераспадающиеся. Есть целые числа, но есть и подсчет в процентах. Это полная каша. - Это где-то здесь, - твердо сказала Сьюзан.

Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

Внезапно его швырнуло назад, и он больно ударился спиной о кожух генератора. Пытаясь подняться на ноги, Стратмор в ужасе смотрел на предмет, зажатый в его пальцах: это была рука Чатрукьяна, обломившаяся в локтевом суставе. Наверху Сьюзан ждала возвращения коммандера, сидя на диване в Третьем узле словно парализованная.


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