File Name: sustained release and controlled release formulations .zip
Once production of your article has started, you can track the status of your article via Track Your Accepted Article. Help expand a public dataset of research that support the SDGs.
Nifedipine is a calcium channel blocker, which has short half-life, makes the development of sustained release SR dosage form. The present work was to formulate a sustained release matrix dosage form of Nifedipine by using hydrophilic polymer HPMC and hydrophobic polymer Ethyl cellulose to achieve better bioavailability and also to reduce dosing frequency and side-effects. Nifedipine matrix tablets were prepared by direct compression method. FT-IR spectra revealed that there was no interaction between drug and polymers. Tablets were subjected to In-Vitro drug release in 0. So, NF2 was selected as the best formulation.
The present invention is directed to formulations for preparing sustained release drug dosage forms useful for releasing pharmaceuticals at controlled rates for oral administration. A controlled release profile from a drug dosage form is sometimes desirable in clinical use to reduce side effects and improve patient compliance. The technology used to formulate sustained release dosage forms is well documented. The entrapment of a drug in a polymer based matrix is a common approach to formulate sustained release tablets with a desirable release profiles. It has been reported that depot drug formulations for controlled release of pharmaceutical drugs may be prepared using alginates alone see U. It is also known that the use of alginates alone for this purpose often presents difficulties in tableting, film coating and storage. Using a low viscosity of hydroxypropyl methylcellulose with ethylcellulose as rate controlling agents in the formulation may give a shorter T max time to peak blood concentration after oral administration due to a fast tablet erosion.
The development of controlled — release formulations should be based on a clinico-pharmacological rationale such as increased compliance, reduced side effects and improved efficacy. The pharmacokinetic profile of a controlled — release formulation and its dose regimen should be compared under steady-state conditions with that of an immediate — release formulation or that of another controlled — release formulation. The pharmacokinetic steady — state profile should be reproduced with and without food, from day to day, and at various dose levels. This is a preview of subscription content, access via your institution. Rent this article via DeepDyve. Koch-Weser J, Schechter P.
RIS file. However, the range of drugs for which clinically significant advantages have been shown is limited. Prescribers and pharmacists should be aware of the costs of these products and have a knowledge of their clinical use in selected patient groups. In some instances, the formulation is probably serving a marketing objective rather than a clinical objective. Drug products designed to reduce the frequency of dosing by modifying the rate of drug absorption have been available for many years. Advances in technology have resulted in novel oral modified-release dosage forms. Many terms are used to describe modified-release products including extended-release, prolonged-release, controlled-release, controlled-delivery, slow-release and sustained-release.
Objective: The objective of this study was to formulate and evaluate sustained release tablets using cashew gum and cross-linked cashew gum as controlled release polymer. Methods: Full factorial design of 2 3 was employed to optimize the formulation. Tablets were prepared by direct compression and powder properties were evaluated indicating fairly good flow properties. Prepared tablets were evaluated for weight variation, hardness, friability, drug content and for dissolution profile. The optimized formulation obtained from the factorial design was subjected to in vivo studies. Results: In vitro dissolution, swelling and erosion studies were carried out for 12 h in the specified buffer solution.
It seems that you're in Germany. We have a dedicated site for Germany. Editors: Wilson , Clive G. Such optimized design requires a broad knowledge base of topics such as gastro intestinal tract physiology, polymer science, and the mechanisms by which drugs are released from the formulated units. Such knowledge must be allied to the physico chemical properties of the drug, its pharmacokinetic behaviors, enzyme susceptibility and other factors that can affect absorption or timecourse in the biosystem.
Methods: MK was prepared by cross-linking karaya gum with tri-sodium tri-metaphosphate STMP which was used as a cross-linker. The matrix tablets were evaluated for pharmacotechnical properties and in vitro release, including release kinetics. The optimized formulation was compared with Dilzem SR which served as reference.
If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Please consult the latest official manual style if you have any questions regarding the format accuracy. Most conventional immediate release oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration. In the formulation of conventional drug products, no deliberate effort is made to modify the drug release rate.
The purpose of this study was to prepare sustained release tablet of moisture sensitive drug like Ranitidine Hydrochloride for treatment of gastroesophageal reflux disease along with the improvement of moisture stability to get better therapeutic efficacy. Pan coating technique was used for coating of the tablet. Drug and excipient compatibility was done using differential scanning calorimetry and Fourier transform infrared spectroscopy study. The tablet was evaluated for precompression parameter and all postcompression parameter. Tablets were passing out all precompression parameter along with postcompression parameter. Stability study shows that the parameter such as hardness, friability, and dissolution are in the range. Hence, there is no significant change shown after stability study.
If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Please consult the latest official manual style if you have any questions regarding the format accuracy. Most conventional immediate release oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration. In the formulation of conventional drug products, no deliberate effort is made to modify the drug release rate. Immediate-release products generally result in relatively rapid drug absorption and onset of accompanying pharmacodynamic effects. In the case of conventional oral products containing prodrugs, the pharmacodynamic activity may be slow due to conversion to the active drug by hepatic or intestinal metabolism or by chemical hydrolysis. Alternatively, conventional oral products containing poorly soluble lipophilic drugs , drug absorption may be gradual due to slow dissolution in or selective absorption across the GI tract, also resulting in a delayed onset time.
Modified-release dosage is a mechanism that in contrast to immediate-release dosage delivers a drug with a delay after its administration delayed-release dosage or for a prolonged period of time extended-release [ER, XR, XL] dosage or to a specific target in the body targeted-release dosage. Sustained-release dosage forms are dosage forms designed to release liberate a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through a variety of formulations, including liposomes and drug-polymer conjugates an example being hydrogels. Sustained release's definition is more akin to a "controlled release" rather than "sustained". Extended-release dosage consists of either sustained-release SR or controlled-release CR dosage. SR maintains drug release over a sustained period but not at a constant rate. CR maintains drug release over a sustained period at a nearly constant rate.
Из тени на авенида дель Сид появилась фигура человека. Поправив очки в железной оправе, человек посмотрел вслед удаляющемуся автобусу. Дэвид Беккер исчез, но это ненадолго. Из всех севильских автобусов мистер Беккер выбрал пользующийся дурной славой 27-й маршрут. Автобус номер 27 следует к хорошо известной конечной остановке.
Коммандер Тревор Стратмор снова стал самим собой - человеком железной логики и самообладания, делающим то, что полагалось делать. Последние слова предсмертной записки Хейла крутились у нее в голове, не повинуясь никаким приказам. И в первую очередь я искренне сожалею о Дэвиде Беккере.
Сомнения, которые его одолевали, исчезли, как только он встретился с коммандером Стратмором. У них состоялся откровенный разговор о его происхождении, о потенциальной враждебности, какую он мог испытывать к Соединенным Штатам, о его планах на будущее. Танкадо прошел проверку на полиграф-машине и пережил пять недель интенсивного психологического тестирования. И с успехом его выдержал. Ненависть в его сердце уступила место преданности Будде.
Шифр не поддается взлому, - сказал он безучастно. Не поддается. Сьюзан не могла поверить, что это сказал человек, двадцать семь лет работавший с шифрами. - Не поддается, сэр? - с трудом произнесла. - А как же принцип Бергофского.
- Нужно найти ключ Хейла. Сьюзан замолчала. Коммандер, как всегда, прав. Им необходим ключ, который хранится у Хейла.
Но потом поняла, куда смотрел коммандер: на человеческую фигуру шестью этажами ниже, которая то и дело возникала в разрывах пара. Вот она показалась опять, с нелепо скрюченными конечностями.
Your email address will not be published. Required fields are marked *